PD-L1 anticorps

N° du produit ABIN7670558

Cet anticorps Souris Monoclonal détecte spécifiquement PD-L1 dans ELISA (Detection). Il présente une réactivité envers Humain.

Aperçu rapide pour PD-L1 anticorps (ABIN7670558)

Antigène: PD-L1 (CD274 (PD-L1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-L1 est non-conjugé

Application: ELISA (Detection)

Clone: 5A7

Détail du produit anti-PD-L1 anticorps

Fonction: PD-L1 Monoclonal Antibody(Detector)

Purification: Protein A/G Purification

Immunogène: Recombinant Human PD-L1 L1 protein expressed by Mammalian

Isotype: IgG2a

Information d'application

Indications d'application: ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Date de péremption: 12 months

Détails sur PD-L1

Antigène: PD-L1 (CD274 (PD-L1))

Autre désignation: PD-L1

Sujet: CD274,B7H1,PDCD1L1,PDCD1LG1,PDL1,PD-L1,Programmed ceLL death 1 Ligand 1,B7 homoLog 1,PDCD1 Ligand 1,Programmed death Ligand 1,hPD-L1,Plays a critical role in induction and maintenance of immune tolerance to self.As a ligand for the inhibitory receptor PDCD1/PD-1,modulates the activation threshold of T-cells and limits T-cell effector response.Through a yet unknown activating receptor,may costimulate T-cell subsets that predominantly produce interleukin-10 (Il10).Can also act as a transcription coactivator: in response to hypoxia,translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC,leading to pyroptosis.The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system,thereby facilitating tumor survival.The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTls) effector function. The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response,providing a rationale for cancer immunotherapy.

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints